2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone

HRID 372342

반응식

HRID 372342 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]=[O:9])=[C:4]([CH3:12])[CH:3]=1.[C:13]([NH2:17])(=[O:16])[CH2:14]O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]2[NH:17][C:13](=[O:16])[CH2:14][O:9]2)=[C:4]([CH3:12])[CH:3]=1

참가 물질

5

반응물 2

HCID 690212-HydroxyacetamideHCID 123914592-(4-Chloro-2-methylphenoxy)acetaldehyde

생성물 1

HCID 123914922-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone수율 18.2%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution containing 4.6g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.

후처리

  1. washThe resulting product was washed with 5% sodium carbonate and water
  2. customdried
  3. custompurified by silica chromatography

출처 및 근거

ORD 기록
ord-2005a2a0641041d69c36b39cd9a7f613
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04090861

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