Hydrochloric Acid → 4-amino-3,4-dihydro-2H-naphthalen-1-one
반응식
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12]C(=O)C)[CH2:4][CH2:3]1.Cl>O>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH2:12])[CH2:4][CH2:3]1참가 물질
4
실험 절차
A mixture of 41.4 g. of crude N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)acetamide, 300 ml. of concentrated hydrochloric acid and 250 ml. of water is stirred and heated at reflux overnight. The mixture is decanted, filtered, and the cooled filtrate is extracted with 300 ml. of chloroform. The aqueous solution is evaporated to dryness in vacuo to afford 26.55 g. of the title product.
후처리
- additionA mixture of 41.4 g
- temperatureheated
- temperatureat reflux overnight
- customThe mixture is decanted
- filtrationfiltered
- extractionthe cooled filtrate is extracted with 300 ml
- customThe aqueous solution is evaporated to dryness in vacuo
- customto afford 26.55 g
출처 및 근거
- ORD 기록
- ord-a0760faea9874285bc4d7a9d3c913d90
- 출처 데이터셋
- uspto-grants-1978_05
- 특허 번호
- US04091018
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