Acetic Anhydride → (S)-N-(1,2,3,4-tetrahydro-1-naphthyl-1-naphthyl)acetamide

HRID 372398

반응식

HRID 372398 반응식
[C@@H:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(O[C:16](=[O:18])[CH3:17])(=O)C>C1(C)C=CC=CC=1>[C@@H:9]1([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[NH:11][C:16](=[O:18])[CH3:17])[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH2:6][CH2:7][CH2:8]1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 70580741-Aminotetralin, (S)-

생성물 1

HCID 70619608(S)-N-(1,2,3,4-tetrahydro-1-naphthyl-1-naphthyl)acetamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(S)-1,2,3,4-tetrahydro-1-naphthylamine (26.9 g.) is dissolved in 200 ml. of toluene and 36 g. of acetic anhydride is added while the temperature from the reaction exotherm is moderated at 50° C. to 60° C. with an ice-bath. The solution is heated to reflux for 0.5 hr. and then stirred at room temperature overnight. The mixture is then evaporated to dryness and the residue is washed well with ether. On drying, 26.1 g. of the title compound, m.p. 153° C. to 155° C., is obtained.

후처리

  1. customis moderated at 50° C. to 60° C. with an ice-bath
  2. temperatureThe solution is heated
  3. temperatureto reflux for 0.5 hr
  4. customThe mixture is then evaporated to dryness
  5. washthe residue is washed well with ether
  6. customOn drying

출처 및 근거

ORD 기록
ord-e4665fed39504738b9c5d341cd336482
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04091018

연결된 노트

불러오는 중…