4-Chloro-8-(trifluoromethyl)quinoline → dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

HRID 372453

반응식

HRID 372453 반응식
[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].Cl[C:17]1[C:26]2[C:21](=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:24][CH:25]=2)[N:20]=[CH:19][CH:18]=1>C(O)(C)C.Cl>[F:30][C:27]([F:28])([F:29])[C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:21]=1[N:20]=[CH:19][CH:18]=[C:17]2[NH:4][C:3]1[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])=[O:9]

참가 물질

5

반응물 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 12669155Dimethylphosphinylmethyl anthranilate

생성물 1

HCID 12669152dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3776Isopropanol용매

실험 절차

4.6 grams (0.02 mol) of dimethylphosphinylmethyl anthranilate and 4.6 grams (0.02 mol) of 4-chloro-8-trifluoromethylquinoline are kept at 80° C for about 31/2 hours in 15 ml of isopropanol and 2.3 ml of concentrated aqueous hydrochloric acid. After removing the solvents and excess hydrochloric acid, the free base of the ester is liberated at 0° C. The dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate obtained is identical to that prepared in Example (2a). Yield 7.6 grams (90% of theory).

후처리

  1. customare kept at 80° C for about 31
  2. customAfter removing the solvents and excess hydrochloric acid
  3. customis liberated at 0° C

출처 및 근거

ORD 기록
ord-73834c741bfc439da9a72fcec4cc69fd
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04091095

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