Azobisisobutyronitrile → HCID 12669153, 화합물

HRID 372454

반응식

HRID 372454 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[C:14](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:15]([O:17][CH2:18][CH:19]=[CH2:20])=[O:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:25][PH:26](=[O:28])[CH3:27].N(C(C)(C)C#N)=NC(C)(C)C#N>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[C:14](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:15]([O:17][CH2:18][CH2:19][CH2:20][P:26]([CH3:27])([CH3:25])=[O:28])=[O:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 12669156HCID 12669156, 화합물HCID 178503022methylphosphonoylmethane2회

생성물 1

HCID 12669153HCID 12669153, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A mixture of 3.37 grams (0.01 mol) of allyl 7-chloro-4-quinolyl-anthranilate (melting point 112° C) dissolved in 60 ml of toluene and 1.17 grams (0.015 mol) of dimethylphosphine oxide is heated to 100° C. 30 mg of α,α'-azo-bis-isobutyronitrile in 10 ml of toluene are then added dropwise to catalyse the addition of the dimethylphosphine oxide to the allyl double bond. From the cooled solution, 3-(dimethylphosphinyl)-propyl N-(7-chloro-4-quinolyl)-anthranilate is isolated; melting point 162° C (after recrystallisation from acetone); yield: 3.58 grams (86% of theory).

출처 및 근거

ORD 기록
ord-09880d6cf1c94983ae69e6d795528ae9
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04091095

연결된 노트

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