Benzyl Alcohol → HCID 12900144, 화합물

HRID 372676노트

반응식

HRID 372676 반응식
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].Cl[C:12]1[NH:17][C:16](=[O:18])[C:15]([F:19])=[CH:14][N:13]=1>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:12]1[NH:17][C:16](=[O:18])[C:15]([F:19])=[CH:14][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 2553942-Chloro-5-fluoropyrimidin-4-ol

생성물 1

HCID 12900144HCID 12900144, 화합물수율 78.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A 100 ml quantity of benzyl alcohol and 7.2 g of sodium hydride are added to 100 ml of absolute toluene, and the mixture is refluxed for 1 hour. Subsequently 14.9 g of 2-chloro-5-fluoropyrimidin-4-one is added to the reaction mixture, and the resulting mixture is heated in a sealed tube at 140° to 150° C for 6 hours for reaction. The reaction mixture is further treated in the same manner as in Example 6 to give 17.2 g of white crystalline 2-benzyloxy-5-fluoropyrimidin-4-one in a yield of 78.2%, m.p. 146°-147° C.

후처리

  1. temperaturethe mixture is refluxed for 1 hour
  2. temperaturethe resulting mixture is heated in a sealed tube at 140° to 150° C for 6 hours for reaction
  3. additionThe reaction mixture is further treated in the same manner as in Example 6

출처 및 근거

ORD 기록
ord-40c3e0197139444d8126ffc065cb2a63
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092313

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