Ethylenediamine → 4-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

HRID 372690

반응식

HRID 372690 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[CH3:15][N:16](C)C=O.C(N)CN>O>[C:15]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)#[N:16]

참가 물질

5

반응물 3

HCID 3301EthylenediamineHCID 6228DimethylformamideHCID 6890736-(4-Bromophenyl)-2,3-dihydropyridazin-3-one

생성물 1

HCID 194194914-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 19.20 g. portion of 6-(p-bromophenyl)-3(2H)-pyridazinone is mixed with 9.10 g. of cuprous cyanide in 70 ml. of dimethylformamide and stirred at reflux temperature for 12 hours. The hot mixture is poured into a solution of 46 ml. of ethylenediamine in 230 ml. of water. The mixture is stirred at ice-bath temperature for 30 minutes and the solid is separated by filtration. A second crop forms in the filtrate which is collected and added to the first crop which is then washed with water yielding 6-(p-cyanophenyl)-3(2H)-pyridazinone.

후처리

  1. temperatureat reflux temperature for 12 hours
  2. additionThe hot mixture is poured into a solution of 46 ml
  3. customthe solid is separated by filtration
  4. customA second crop forms in the filtrate which is collected
  5. additionadded to the first crop which
  6. washis then washed with water

출처 및 근거

ORD 기록
ord-4296f7fe678e41928dd3210e7571eb17
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092311

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