Hydrochloric Acid → N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea

HRID 37292

반응식

HRID 37292 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH3:23])[C:17]=1[N:24]=[C:25]=[O:26])[CH3:15].N1C=CC=CC=1.Cl>ClCCl>[CH2:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH3:23])[C:17]=1[NH:24][C:25]([NH:13][CH:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)=[O:26])[CH3:15]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 298974-PhenylcyclohexylamineHCID 51531832,6-Diethylphenyl isocyanate

생성물 1

HCID 19935160N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1 g of 4-phenylcyclohexylamine in 10 ml of dichloromethane was added 2,6-diethylphenylisocyanate dropwise in the presence of pyridine and the mixture was stirred for 2 hours at room temperature. To the resultant mixture was added 30 ml of diluted hydrochloric acid and the solution was extracted with chloroform. The extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine, and then dried over magnesium sulfate. The solvent was distilled away and the residue was crystallized from methanol to give 0.4 g of N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea, melting at 247°-249° C.

후처리

  1. extractionthe solution was extracted with chloroform
  2. washThe extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent was distilled away
  5. customthe residue was crystallized from methanol

출처 및 근거

ORD 기록
ord-c23ebd5f61fc415c985902eea7eba4c6
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420164

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