Pyrazole → 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole

HRID 373006

반응식

HRID 373006 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16]Br)[CH2:9][CH2:8]1.[NH:18]1[CH:22]=[CH:21][CH:20]=[N:19]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)[CH2:9][CH2:8]1

참가 물질

5

반응물 3

HCID 1048PyrazoleHCID 11430Potassium CarbonateHCID 147268432-(4-(4-Bromobutyl)piperazin-1-yl)pyrimidine

생성물 1

HCID 110443661-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4 g (13.3 mmol) of 1-(2-pyrimidinyl)-4-(4-bromobutyl)piperazine, 1.02 g (15 mmol) of pyrazole and 2.76 g (20 mmol) of potassium carbonate in 50 ml of dimethylformamide is heated to reflux for 14 hours. The mixture is evaporated under vacuum, chloroform is added, the organic phase is washed with water, dried over sodium sulphate and evaporated under vacuum, and 3.5 g of an oil which is 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole are obtained.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 14 hours
  3. customThe mixture is evaporated under vacuum, chloroform
  4. additionis added
  5. washthe organic phase is washed with water
  6. dry with materialdried over sodium sulphate
  7. customevaporated under vacuum, and 3.5 g of an oil which
  8. customare obtained

출처 및 근거

ORD 기록
ord-88d5f208d48e4fefa8dfa751ff185f9e
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162323

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