Triethylamine → 2-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one

HRID 373122

반응식

HRID 373122 반응식
Cl.[C:2]([NH2:8])(=[NH:7])[CH2:3][CH2:4][CH2:5][CH3:6].[CH2:9]([CH:11]([C:17]([CH3:19])=O)[C:12](OCC)=[O:13])[CH3:10].C(N(CC)CC)C>CN(C=O)C.[Cl-].[Na+].O>[CH2:3]([C:2]1[NH:8][C:12](=[O:13])[C:11]([CH2:17][CH3:19])=[C:9]([CH3:10])[N:7]=1)[CH2:4][CH2:5][CH3:6]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl esterHCID 11615174Pentanimidamide Hydrochloride

생성물 1

HCID 1356254552-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 57417360Sodium chloride; water용매

실험 절차

A solution of 3.0 g valeramidine hydrochloride, 3.47 g ethyl 2-ethylacetoacetate, and 5.8 mL triethylamine in 20 mL DMF was heated to 120° C. for 18 hours. The mixture was diluted with brine and extracted three times with ether. The combined organic material was washed with brine, was dried over MgSO4, was stripped of solvent in vacuo, and then was still flash chromatographed in 3% MeOH in CH2Cl2 to give the title compound as a white solid.

후처리

  1. extractionextracted three times with ether
  2. washThe combined organic material was washed with brine
  3. dry with materialwas dried over MgSO4
  4. customchromatographed in 3% MeOH in CH2Cl2

출처 및 근거

ORD 기록
ord-2c1dd5fc50af494f8e30ecfcd63b6475
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162325

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