Ethylenediamine → Dodecanamide, N-(2-aminoethyl)-

HRID 373197

반응식

HRID 373197 반응식
[C:1]([O:14]CC)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH2:17]([NH2:20])[CH2:18][NH2:19]>O1CCCC1>[NH2:19][CH2:18][CH2:17][NH:20][C:1](=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 3301EthylenediamineHCID 7800Ethyl Dodecanoate

생성물 1

HCID 82394Dodecanamide, N-(2-aminoethyl)-수율 44.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

A solution of 23 g of ethyl dodecanoate and 62.7 g of ethylenediamine in 100 ml of tetrahydrofuran (THF) was refluxed for 3 hours and the excess THF was distilled off. The reaction mixture was heated at 100° C. for 16 hours, cooled to room temperature, poured into cold water and extracted with ether. After drying, the organic solution was concentrated to give 15.7 g of crude product and this was recrystallized from ether-hexane to give 10.9 g of pure product, m.p. 64°-66° C.

후처리

  1. distillationthe excess THF was distilled off
  2. temperaturecooled to room temperature
  3. additionpoured into cold water
  4. extractionextracted with ether
  5. customAfter drying
  6. concentrationthe organic solution was concentrated
  7. customto give 15.7 g of crude product
  8. customthis was recrystallized from ether-hexane

출처 및 근거

ORD 기록
ord-4ba5e978f6544351a643c1f9b3b0d08d
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162315

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