Acetic Anhydride → 1-[(4-Morpholino)phenylsulphonyl]-2-pyrrolidinone

HRID 373716노트

반응식

HRID 373716 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH:17](CC)[C:18](O)=O)(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[C:23]([O-:26])(=O)[CH3:24].[Na+].C(OC(=O)C)(=O)C>>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([N:16]3[CH2:17][CH2:18][CH2:24][C:23]3=[O:26])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 19811002(4-Morpholinophenylsulphonylamino)butyric acid

생성물 1

HCID 104706421-[(4-Morpholino)phenylsulphonyl]-2-pyrrolidinone수율 96.4%

실험 절차

6.2 g of product obtained in Stage A, 6.2 g of sodium acetate and 124 cm3 of acetic anhydride are heated to reflux for 4 hours. After cooling to ambient temperature and evaporating to dryness, the residue is taken up with 50 cm3 of water, filtered, washed with 10 cm3 of water and dried. 5.65 g of expected product is obtained.

후처리

  1. temperatureto reflux for 4 hours
  2. customevaporating to dryness
  3. filtrationfiltered
  4. washwashed with 10 cm3 of water
  5. customdried

출처 및 근거

ORD 기록
ord-7773de1da012409a9457600be7d73f65
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05164514

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