6-Nitroquinolin-2(1H)-one → 6-Aminoquinolin-2-ol

HRID 373784노트

반응식

HRID 373784 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]=[CH:7]2)([O-])=O.[H][H]>CO.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]=[CH:7]2

참가 물질

5

반응물 2

HCID 8999326-Nitroquinolin-2(1H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 128107976-Aminoquinolin-2-ol

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

In a Parr catalytic hydrogenation apparatus 6-nitrocarbostyril, 5.3 g (0.028 mole), in 150 mL of methanol and 0.5 g PtO2 were shaken in a hydrogen atmosphere. The resulting yellow solid was extracted with refluxing methanol to yield 6-aminocarbostyril, 3.5 g, as yellow crystals; m.p. 315°-317° C.

후처리

  1. extractionThe resulting yellow solid was extracted with refluxing methanol

출처 및 근거

ORD 기록
ord-749a5a7465414875b2f5ab155b7da4de
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166160

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