Acetic Acid → 4-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

HRID 373950

반응식

HRID 373950 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:30]=[CH:29][C:17]([CH:18]=[CH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=[O:13].C(O)(=[O:33])C.OO>ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:15]=[CH:16][C:17]([CH:18]=[CH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:27][CH:28]=2)=[CH:29][CH:30]=1)(=[O:33])=[O:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 545127564-(4-(2-Quinolinylmethylsulfinyl)styryl)benzoic acid

생성물 1

HCID 544571334-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 3 mmol of the sulfinyl compound from Step A in acetic acid (40 mmol) is added 30% hydrogen peroxide (2 ml). The mixture is stirred at ambient temperature and assayed by TLC. Upon disappearance of the sulfinyl starting compound, the reaction mixture is diluted with dichloromethane, washed with dilute aqueous sodium bisulfite and water, dried and evaporated to give 4-(4-(2-quinolinylmethylsulfonyl)styryl)benzoic acid.

후처리

  1. washwashed with dilute aqueous sodium bisulfite and water
  2. customdried
  3. customevaporated

출처 및 근거

ORD 기록
ord-01cf7ebcee884278be3216537458d942
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166210

연결된 노트

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