Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium fluoride → 3'-Fluorothymidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium fluoride | HCID 25516 | — |
| 반응물 | 2,3'-Anhydrothymidine | HCID 6915752 | — |
| 반응물 | Potassium fluoride, 99%, spray-dried | HCID 53443437 | — |
| 반응물 | 3'-Mesylthymidine | HCID 53914209 | — |
| 용매 | Ethylene Glycol | HCID 174 | — |
| 생성물 | 3'-Fluorothymidine | HCID 33039 | 10% |
반응 단계
3'-Mesylthymidine or 2,3'-anhydrothymidine is allowed to react with potassium hydrogen fluoride or ammonium fluoride in ethylene glycol at 191° C. for 10 to 90 minutes, thus giving 3'-deoxy-3'-fluorothymidine (yield: 10 to 14%) [Japanese Patent Publication No. 10472 (1973)].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05166327 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-1691f48da1a64b31970d925a16ff228d |
| 출처 메모 | uspto-grants-1992_11 |