Dimethylhydantoin → Nilutamide

HRID 374125

반응식

HRID 374125 반응식
[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[N+:10]([C:13]1[CH:18]=[CH:17][C:16](Cl)=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21])([O-:12])=[O:11]>C(O)C.[Cu]>[F:21][C:20]([F:22])([F:23])[C:14]1[CH:15]=[C:16]([N:4]2[C:3](=[O:8])[C:2]([CH3:9])([CH3:1])[NH:6][C:5]2=[O:7])[CH:17]=[CH:18][C:13]=1[N+:10]([O-:12])=[O:11]

참가 물질

5

반응물 2

HCID 6491DimethylhydantoinHCID 670525-Chloro-2-nitrobenzotrifluoride

생성물 1

HCID 4493Nilutamide

시약·촉매·용매 2

HCID 23978Copper촉매HCID 702Ethanol용매2회

반응 조건

온도
200 °C

실험 절차

71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.

후처리

  1. temperaturethe pressure being maintained at 450 millibars
  2. temperaturewas cooled to 20° C.

출처 및 근거

ORD 기록
ord-f33c2a567db743aeaaf8f1ed8c025a89
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166358

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