2-Mercaptobenzoic Acid → 2-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid

HRID 3742

반응식

HRID 3742 반응식
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1.[C:21]([OH:30])(=[O:29])[C:22]1[C:23](=[CH:25][CH:26]=[CH:27][CH:28]=1)[SH:24]>CO.O1CCCC1>[S:17]([C:14]1[CH:15]=[CH:16][C:11]([NH:3][C:2]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][S:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[C:21]([OH:30])=[O:29])=[O:1])=[CH:12][CH:13]=1)(=[O:19])(=[O:18])[NH2:20]

참가 물질

5

반응물 2

HCID 54432-Mercaptobenzoic AcidHCID 4629384-(3-Oxo-1,2-benzothiazol-2-yl)benzenesulfonamide

생성물 1

HCID 107663952-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid수율 95.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide in a mixture of 15 mL of methanol and 15 mL of tetrahydrofuran, and 0.23 g (1.5 mmol) of thiosalicylic acid. The product was washed with ether and dried in vacuo to give 0.66 g of the title compound, mp 276°-278° C.

후처리

  1. customThis compound was prepared
  2. washThe product was washed with ether
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-40ccfc0f214f4effb36ca78515638c20
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05734081

연결된 노트

불러오는 중…