Sodium Carbonate → 2-Deoxy-2-methacrylamido-D-glucose

HRID 374403

반응식

HRID 374403 반응식
Cl.[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].C(=O)([O-])[O-].[Na+].[Na+].N([O-])=O.[Na+].[C:24](Cl)(=[O:28])[C:25]([CH3:27])=[CH2:26]>O>[C:24]([NH:5][C@H:4]([C@H:6]([C@@H:8]([C@@H:10]([CH2:12][OH:13])[OH:11])[OH:9])[OH:7])[CH:3]=[O:2])(=[O:28])[C:25]([CH3:27])=[CH2:26]

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 13528Methacryloyl chlorideHCID 2723635(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochlorideHCID 23668193Sodium Nitrite

생성물 1

HCID 227925012-Deoxy-2-methacrylamido-D-glucose

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Glucosamine hydrochloride ( 0.06 mol; 13.25 g), sodium carbonate (0.2 mol; 21.2 g) and sodium nitrite (0.2 g) were dissolved under nitrogen atmosphere at 0° C. in 100 ml of H2O. Methacryloyl chloride (0.12 mol; 13.0 g) was added under vigorous stirring. The reaction was carried out similar to the synthesis of 1 and gave the product as a white powder after two recrystallizations from water/ethanol/ether. Yield: 8.3-8.9 g (56-60%), p.m. (decomp.): 198°-199° C.

후처리

  1. customThe reaction was carried out similar to the synthesis of 1

출처 및 근거

ORD 기록
ord-41296acd823f4e30b817cb0f000853f6
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480790

연결된 노트

불러오는 중…