DL-Arabinose → Pentosidine

HRID 374409

반응식

HRID 374409 반응식
[CH2:1](O)[CH:2](O)[CH:3](O)[CH:4](O)[CH:5]=O.[NH2:11][C@H:12]([C:18]([OH:20])=[O:19])[CH2:13][CH2:14][CH2:15][CH2:16][NH2:17].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28].O=C[C@@H]([C@@H]([C@@H](CO)O)O)O>>[CH:2]1[CH:3]=[C:4]2[C:5](=[N:29][C:27]([NH:26][CH2:25][CH2:24][CH2:23][C@H:22]([NH2:21])[C:30]([OH:32])=[O:31])=[N:28]2)[N:17]([CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH2:11])[C:18]([OH:20])=[O:19])[CH:1]=1

참가 물질

5

반응물 4

HCID 854DL-ArabinoseHCID 5962L-LysineHCID 5311110Aldehydo-D-riboseHCID 178418600HCID 178418600, 화합물

생성물 1

HCID 119593Pentosidine

반응 조건

온도
80 °C

실험 절차

In order to confirm the pentose-derived nature of the native fluorophore 100 mM each of L-lysine, L-arginine and D-ribose were heated for 1 hour at 80° C. Injection of a small amount of this synthetic material on HPLC revealed a major fluorescent peak coeluting with the native fluorophore. (see FIG. 5) In order to substantiate the proposed structure, the synthetic fluorophore was prepared preparatively and purified. Total yield was 21 mg; i.e., 0.02% of the reactants.

후처리

  1. customthe synthetic fluorophore was prepared preparatively
  2. custompurified

출처 및 근거

ORD 기록
ord-8357ab42bf30496287c2be5cf03b34d8
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480807

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