Bromine → 2-(Bromoacetyl)-5-chlorothiophene

HRID 374523

반응식

HRID 374523 반응식
[Br:1]Br.[C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].CCOCC.CCCCCC>C(Cl)(Cl)Cl.O>[Br:1][CH2:4][C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[O:5]

참가 물질

6

반응물 3

HCID 24408BromineHCID 805722-Acetyl-5-chlorothiopheneHCID 21584099Diethylether hexane

생성물 1

HCID 20636342-(Bromoacetyl)-5-chlorothiophene수율 43.2%

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매2회

실험 절차

A solution of bromine (18.90 g, 118 mmol) in chloroform is added to a solution of 2-acetyl-5-chlorothiophene (19.00 g, 118 mmol) in chloroform at 40°-45° C. The reaction mixture is stirred at room temperature for two hours and diluted with water. The organic layer is separated, dried over MgSO4 and concentrated in vacuo to give a solid. The solid is slurried in an ether/hexane solution, filtered and dried to give the title product as a solid (12.20 g, mp 68°-70° C.).

후처리

  1. customThe organic layer is separated
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customto give a solid
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-c3a9920f6fd74ed38401012bf093bc09
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480902

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