Hydrochloric Acid → (4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride

HRID 374554노트

반응식

HRID 374554 반응식
C([N:8]1[C@@H:16]2[C@@H:12]([CH2:13][NH:14][CH2:15]2)[O:11][CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:17]>C(O)C.[Pd]>[ClH:17].[ClH:17].[C@@H:12]12[CH2:13][NH:14][CH2:15][C@@H:16]1[NH:8][CH2:9][CH2:10][O:11]2

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 10856960rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

생성물 1

HCID 22857293(4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

26 g (0.11 mol, 92% strength) of cis-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are hydrogenated on 3 g of palladium/active charcoal (10% Pd) at 100° C. and 100 bar H2 in 180 ml of ethanol and 19 ml of concentrated hydrochloric acid. The catalyst is filtered off with suction, the filtrate is concentrated and the crystals which have separated out are dried in a desiccator over phosphorus pentoxide.

후처리

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. customthe crystals which have separated out
  4. dry with materialare dried in a desiccator over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-ccf30365f6c34b6d8d579e5f4381522a
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480879

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