Trifluoroacetic acid → Caprine

HRID 374684

반응식

HRID 374684 반응식
C([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH2:10][CH2:11][CH3:12])[NH2:8])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@H:7]([C:6]([OH:13])=[O:5])[CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 12451446tert-butyl (2S)-2-aminohexanoate

생성물 1

HCID 21236Caprine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

23.5 mg of L-N-[(2R or S)-5-ethylthio-2-(1-naphthylmethyl)pentanoyl]norleucine tert-butyl ester was dissolved in 0.2 ml of dichloromethane, and 0.1 ml of trifluoro acetic acid was added thereto. The mixture was stirred at room temperature for four hours. Then, the reaction solution was concentrated under reduced pressure to obtain 20.7 mg of L-N-[(2R or S)-5-ethylthio-2-(1-naphthylmethyl)pentanoyl]norleucine as colorless solid.

후처리

  1. concentrationThen, the reaction solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-aa312e5f1bd544c6952f2a6f19a3f20f
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05481036

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