Hydrazine hydrate (1:1) → HCID 15289591, 화합물

반응식

[NH2:1][C:2]1[C:3]([CH3:19])=[N:4][C:5](Cl)=[C:6]([C:13](OCC)=[O:14])[C:7]=1[C:8](OCC)=[O:9].O.[NH2:21][NH2:22]>>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:22][NH:21][C:13](=[O:14])[C:6]=2[CH:5]=[N:4][C:3]=1[CH3:19]

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 15289693Diethyl 5-amino-2-chloro-6-methylpyridine-3,4-dicarboxylate

생성물 1

HCID 15289591HCID 15289591, 화합물

반응 조건

온도: 100 °C

실험 절차

To 57 mg of 3-amino-6-chloro-4,5-diethoxycarbonyl-2-methylpyridine was added 0.5 ml of hydrazine monohydrate, and the mixture was heated in a stream of nitrogen at 100° C. for 30 minutes. The solvent is distilled off, and the resultant crystals were collected by filtration with ethanol. After water was added to the crystals, the mixture was neutralized with 1N hydrochloric acid.

후처리

distillationThe solvent is distilled off
filtrationthe resultant crystals were collected by filtration with ethanol
additionAfter water was added to the crystals

출처 및 근거

ORD 기록: ord-23d374163e39458eb369e1c6a6d75ce3
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05420275

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