Water → Benzyl 3-hydroxypyrrolidine-1-carboxylate

HRID 374809

반응식

HRID 374809 반응식
[NH:1]1[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]1.[CH2:7]([O:14][C:15](Cl)=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(Cl)(Cl)Cl.C(N(CC)CC)C>[CH2:7]([O:14][C:15]([N:1]1[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]1)=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 10387Benzyl chloroformateHCID 982104-Hydroxypyrrolidine

생성물 1

HCID 560953Benzyl 3-hydroxypyrrolidine-1-carboxylate

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 8471Triethylamine용매

실험 절차

30 g of 3-pyrrolidinol was dissolved in 500 ml of chloroform, to which 53 ml of triethylamine was added, followed by gradually dropping 52 ml of benzyloxycarbonyl chloride at room temperature. After completion of the reaction, the reaction solution was poured into water and extracted with chloroform. The solvent was distilled off under reduced pressure and the resultant residue was purified by column chromatography (eluting solvent: hexane-ethyl acetate) to obtain 70.67 g of the intended compound.

후처리

  1. additionwas added
  2. customat room temperature
  3. customAfter completion of the reaction
  4. extractionextracted with chloroform
  5. distillationThe solvent was distilled off under reduced pressure
  6. customthe resultant residue was purified by column chromatography (eluting solvent: hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-622ec98462384e448b3f2b77ee2bbe73
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05482937

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