Hydrazine hydrate (1:1) → HCID 15289591, 화합물

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[NH2:1][C:2]1[C:3]([CH3:18])=[N:4][CH:5]=[C:6]([C:13](OCC)=[O:14])[C:7]=1[C:8](OCC)=[O:9].O.[NH2:20][NH2:21]>>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:21][NH:20][C:13](=[O:14])[C:6]=2[CH:5]=[N:4][C:3]=1[CH3:18]

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 15289695Diethyl 5-amino-6-methylpyridine-3,4-dicarboxylate

생성물 1

HCID 15289591HCID 15289591, 화합물

반응 조건

온도: 100 °C

실험 절차

To 57 mg of 3-amino-4,5-diethoxycarbonyl-2-methylpyridine was added 0.5 mL of hydrazine monohydrate, and the mixture was heated at 100° C. in a stream of nitrogen for 30 minutes. After the solvent was distilled off, the resulting crystals were collected by filtration with ethanol. Water was added to the crystals, and the mixture was neutralized with 1N hydrochloric acid, followed by collection of the crystals by filtration.

후처리

distillationAfter the solvent was distilled off
filtrationthe resulting crystals were collected by filtration with ethanol
additionWater was added to the crystals
filtrationfollowed by collection of the crystals by filtration

출처 및 근거

ORD 기록: ord-727693d69aa2469abc25a8ff25403163
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05420275

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