Allyl bromide → N-allyl-N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

HRID 3750

반응식

HRID 3750 반응식
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][S:10]([C:13]1[N+:14]([O-:19])=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11].[H-].[Na+].[CH2:24](Br)[CH:25]=[CH2:26]>CN(C=O)C>[CH2:26]([N:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:20])([F:1])[F:21])[S:10]([C:13]1[N+:14]([O-:19])=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11])[CH:25]=[CH2:24]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 20152991N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

생성물 1

HCID 14097714N-allyl-N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide (compound 129, Table A) (1.0 g, 3.0 mmol) in 10 ml of DMF is added NaH (0.30 g, 6.2 mmol) under N2, and the mixture is stirred at RT for 30 minutes. Allyl bromide (0.82 g, 0.59 ml, 6.8 mmol) is added dropwise, and the mixture is stirred at RT for 48 hours. It is then worked up and purified to give the title compound (compound 37, Table A). (DMF is dimethylformamide; RT is room temperature.)

후처리

  1. stirringthe mixture is stirred at RT for 48 hours
  2. custompurified

출처 및 근거

ORD 기록
ord-032d77276ec347c0b8611cfd56e26b51
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722749

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