Hydrochloric Acid → 3-Amino-4,5-diethoxycarbonyl-2-phenyl-6-sulfopyridine

HRID 37511노트

반응식

HRID 37511 반응식
C(OC([C:6]1([N+:27]([O-])=O)[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][C:9]([S:17]([OH:20])(=[O:19])=[O:18])=[N:8][CH:7]1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=O)C.Cl>C(O)C>[NH2:27][C:6]1[C:7]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N:8][C:9]([S:17]([OH:20])(=[O:18])=[O:19])=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 199355933,4-Diethoxycarbonyl-3-nitro-2-phenyl-6-sulfopyridine

생성물 1

HCID 152897053-Amino-4,5-diethoxycarbonyl-2-phenyl-6-sulfopyridine수율 152.6%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 0.34 g of 3,4-diethoxycarbonyl-3-nitro-2-phenyl-6-sulfopyridine, 0.41 g of reduced iron and 7 ml of ethanol was heated to 60° C., and then 0.5 ml of conc. hydrochloric acid was added. The mixture was heated under reflux for 20 minutes. After the reaction mixture was concentrated to dryness, the residue was subjected to silica gel column chromatography (eluent:chloroform/methanol 5:1), to give 0.24 g of the title compound as pale yellow crystals.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 20 minutes
  3. concentrationAfter the reaction mixture was concentrated to dryness

출처 및 근거

ORD 기록
ord-a0ae2db61f414b338b9f80a607d7bf72
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420275

반응 노트

불러오는 중…