Ethylamine → N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

HRID 375113

반응식

HRID 375113 반응식
[N+:1]([C:4]1[N:5]=[CH:6][N:7]([CH:9]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:10]([O:12]CC)=O)[CH:8]=1)([O-:3])=[O:2].[CH2:21]([NH2:23])[CH3:22]>C(O)C>[CH2:21]([NH:23][C:10](=[O:12])[CH:9]([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH3:22]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate

생성물 1

HCID 15222339N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-(4-nitro-1H-imidazol-1-yl)octanoate (17 moles, 5.0 g) and ethylamine (20 ml) were stirred in 150 ml ethanol at room temperature for 16 hours. The reaction was added to ice water, extracted with ethyl acetate, washed with water, dried over sodium sulfate and concentrated. The oil crystallized upon standing to yield 3.9 g of N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide. (MS).

후처리

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe oil crystallized

출처 및 근거

ORD 기록
ord-fd4c582d41ef494f8ba2e0064e6fd39f
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484780

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