Hydrazine hydrate (1:1) → 8-Amino-5-methoxy-7-methylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione
반응식
[NH2:1][C:2]1[C:3]([CH3:18])=[N:4][C:5]([O:16][CH3:17])=[C:6]([C:12](OC)=[O:13])[C:7]=1[C:8](OC)=[O:9].O.[NH2:20][NH2:21]>CO>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:21][NH:20][C:12](=[O:13])[C:6]=2[C:5]([O:16][CH3:17])=[N:4][C:3]=1[CH3:18]참가 물질
4
실험 절차
In 8 ml of methanol was dissolved 280 mg of 3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-methylpyridine, and then 0.54 ml (10 eq.) of hydrazine monohydrate was added to the solution. The mixture was refluxed. The resulting crystals were collected by filtration and washed with methanol. The crystals were suspended in water, and the suspension was acidified with hydrochloric acid. The crystals were collected by filtration and washed with water.
후처리
- temperatureThe mixture was refluxed
- filtrationThe resulting crystals were collected by filtration
- washwashed with methanol
- filtrationThe crystals were collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-f4f305908160453da04621d5040e11e3
- 출처 데이터셋
- uspto-grants-1995_05
- 특허 번호
- US05420275
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