Ammonia → 2-Amino-5-chloro-3-nitrobenzotrifluoride
반응식
[N+:1]([C:4]1[C:5](Cl)=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1)([O-:3])=[O:2].[NH3:16]>[Cl-].C([N+](CC)(CC)CC)C.O>[NH2:16][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:9][C:8]([Cl:10])=[CH:7][C:6]=1[C:11]([F:14])([F:13])[F:12]참가 물질
5
반응 조건
- 온도
- 130 °C
실험 절차
260 g of 3-nitro-2,5-dichlorobenzotrifluoride, 130 ml of water and 10 g of tetraethylammonium chloride were introduced into an autoclave as the initial charge, and 120 ml of liquid ammonia were injected. The mixture was then heated to 130° C. and stirred at this temperature for 10 hours. After cooling, the batch was filtered off, the removed precipitate washed with water and dried to give 194 g of 2-amino-3-nitro-5-chloro-benzotrifluoride of melting point 67° C.
후처리
- additioninitial charge
- temperatureAfter cooling
- filtrationthe batch was filtered off
- washthe removed precipitate washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-a445d32d35ca4d908ebac8fafd92fa88
- 출처 데이터셋
- uspto-grants-1996_01
- 특허 번호
- US05484953
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