(2-Pyrrolidinophenyl)acetic acid hydrobromide → (4aRS,7aRS)6-{[2-(1-pyrrolidinyl)phenyl]acetyl}4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole

HRID 375490

반응식

HRID 375490 반응식
Br.[N:2]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][C:14]([OH:16])=O)[CH2:6][CH2:5][CH2:4][CH2:3]1.Cl.[C:18]1([C:24]2([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH:32]3[CH:28]([CH2:29][NH:30][CH2:31]3)[S:27][CH2:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[N:2]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][C:14]([N:30]2[CH2:31][CH:32]3[C:24]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH2:25][CH2:26][S:27][CH:28]3[CH2:29]2)=[O:16])[CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 67745326(2-Pyrrolidinophenyl)acetic acid hydrobromideHCID 67745331(4aRS,7aRS)4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole hydrochloride

생성물 1

HCID 67745328(4aRS,7aRS)6-{[2-(1-pyrrolidinyl)phenyl]acetyl}4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole수율 30.9%

실험 절차

By carrying out the procedure as in Example of Use 1, using 1.85 g of [2-(1-pyrrolidinyl)phenyl]acetic acid hydrobromide and 2.0 g of (4aRS,7aRS)4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole hydrochloride, 0.90 g of (4aRS,7aRS)6-{[2-(1-pyrrolidinyl)phenyl]acetyl}4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole is obtained in the form of white crystals; melting point 166° C.

출처 및 근거

ORD 기록
ord-f3f4f2325da44750b66b45e54d18e8bb
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484942

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