4'-Mercaptoacetanilide → 3-[3-(4-Acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
반응식
[CH3:1][C:2]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([SH:11])=[CH:7][CH:6]=1)=[O:3].[F:12][C:13]1[CH:14]=[C:15]([C:20]2([O:30][CH3:31])[CH2:24][CH2:23][N:22]([CH2:25][C:26]([F:29])([F:28])[F:27])[CH2:21]2)[CH:16]=[C:17](F)[CH:18]=1>>[C:2]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:17]2[CH:16]=[C:15]([C:20]3([O:30][CH3:31])[CH2:24][CH2:23][N:22]([CH2:25][C:26]([F:27])([F:28])[F:29])[CH2:21]3)[CH:14]=[C:13]([F:12])[CH:18]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:1]참가 물질
3
실험 절차
Using an analogous procedure to that described in Example 6, 4-mercaptoacetanilide was reacted with 3-(3,5-difluorophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine to give 3-[3-(4-acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine in 54% yield, m.p. 127°-129° C.
출처 및 근거
- ORD 기록
- ord-24f1aee3b6fd4676991b1100df3f8a97
- 출처 데이터셋
- uspto-grants-1995_05