1-Phenylpiperazine → 1-(But-3-yn-1-yl)-4-phenylpiperazine

HRID 375534노트

반응식

HRID 375534 반응식
C(OS([C:9]1[CH:14]=[CH:13][C:12](C)=[CH:11][CH:10]=1)(=O)=O)CC#C.[C:16]1([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)C=C[CH:19]=[CH:18][CH:17]=1.C(=O)(O)[O-].[Na+]>CN(C)C=O>[CH2:16]([N:22]1[CH2:27][CH2:26][N:25]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:24][CH2:23]1)[CH2:17][C:18]#[CH:19]

참가 물질

5

반응물 3

HCID 70961-PhenylpiperazineHCID 2720203-Butynyl p-toluenesulfonateHCID 516892Sodium Bicarbonate

생성물 1

HCID 189930381-(But-3-yn-1-yl)-4-phenylpiperazine수율 78.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of but-3-ynyl-p-toluenesulfonate (8.97 g), 1-phenylpiperazine (6.49 g) and sodium bicarbonate (3.7 g) in dimethylformamide (100 mL) is stirred at 80° C. for 14 hours. The solvent is evaporated and the residue dissolved in dichloromethane, washed with water and dried over MgSO4. The solution is filtered through silica gel and the product eluted with 10% ethyl acetate/hexanes to give 6.76 g of the title compound as a white solid.

후처리

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved in dichloromethane
  3. washwashed with water
  4. dry with materialdried over MgSO4
  5. filtrationThe solution is filtered through silica gel
  6. washthe product eluted with 10% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-1b1257d60573427cb265f52a07432601
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486517

반응 노트

불러오는 중…