Water → 2-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol

HRID 375578노트

반응식

HRID 375578 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11](O)=[O:12])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[OH:12][CH2:11][CH2:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 27374552,3-Dihydro-5-benzofuranacetic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 212240782-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol수율 73.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of (2,3-dihydro-5-benzofuranyl)acetic acid (4.9 g--see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide solution (1.5 ml) and water (4.5 ml). The mixture was filtered and the inorganic salts were washed with ethyl acetate. The filtrate and washings were combined and evaporated to give the title compound as an oil, (3.3 g), which was characterised by its 1H-NMR spectrum.

후처리

  1. filtrationThe mixture was filtered
  2. washthe inorganic salts were washed with ethyl acetate
  3. customevaporated

출처 및 근거

ORD 기록
ord-5906822431a24b8ea04730d6939a6e27
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486527

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