Methyl iodide → HCID 19935870, 화합물

반응식

[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C:8]([OH:18])([C:11]2[CH:12]=[C:13]([S:16][CH3:17])[S:14][CH:15]=2)[CH2:7]1)=[O:5])[CH3:2].[CH3:19]I>>[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C:8]([O:18][CH3:19])([C:11]2[CH:12]=[C:13]([S:16][CH3:17])[S:14][CH:15]=2)[CH2:7]1)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 6328Methyl iodide

HCID 199358201-Ethoxycarbonyl-3-hydroxy-3-(2-methylthiothien-4-yl)pyrrolidine

생성물 1

HCID 19935870HCID 19935870, 화합물수율 75%

실험 절차

Using an analogous procedure to that described in the second paragraph of the portion of Example 1 which is concerned with the preparation of starting materials, 1-ethoxycarbonyl-3-hydroxy-3-(2-methylthiothien-4-yl)pyrrolidine was reacted with methyl iodide to give 1-ethoxycarbonyl-3-methoxy-3-(2-methylthiothien-4-yl)pyrrolidine as an oil in 75% yield.

출처 및 근거

ORD 기록: ord-07b1ec3f841f4e3a95970065db1360f2
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05420298

반응 노트

불러오는 중…