Hydrochloric Acid → 3-(3-Fluorophenyl)-2-propenoic acid

HRID 375596노트

반응식

HRID 375596 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1.Cl>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[CH:11][C:12]([OH:14])=[O:13]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 680093-Fluorobenzaldehyde

생성물 1

HCID 886063-(3-Fluorophenyl)-2-propenoic acid수율 84.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 3-fluorobenzaldehyde (10 g), malonic acid (15.6 g) and piperidine (0.7 ml) in pyridine (35 ml) was heated at reflux for 3.5 hours. After cooling to room temperature, the reaction mixture was added to a mixture of ice water (210 ml) and conc. hydrochloric acid (56 ml). The precipitate was isolated by filtration and recrystallized from methanol/water to give 3-fluorocinnamic acid (11.3 g).

후처리

  1. temperatureat reflux for 3.5 hours
  2. customThe precipitate was isolated by filtration
  3. customrecrystallized from methanol/water

출처 및 근거

ORD 기록
ord-0ab4bc206d6443ffa8fdff5b852c4ac4
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486541

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