HCID 18992239, 화합물 → 3-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

HRID 375617노트

반응식

HRID 375617 반응식
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=S)[N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 18992239HCID 18992239, 화합물

생성물 1

HCID 153377963-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a mechanically stirred solution of 5 g of 3-methyl-7,8,9,10-tetrahydroazepino[2,1-b]quinazoline-12(6H)-thione in 150 mL of boiling tetrahydrofuran was added in small portions wet Raney nickel (W-2, Davison Chemical, Chattanooga, Tenn.). The progress of the reaction was followed by TLC. When the reaction was complete, the mixture was filtered, solids on the filter were washed thoroughly with tetrahydrofuran and the filtrate was concentrated down. The rest of the workup was identical to that described in method A.

후처리

  1. filtrationthe mixture was filtered
  2. washsolids on the filter were washed thoroughly with tetrahydrofuran
  3. concentrationthe filtrate was concentrated down

출처 및 근거

ORD 기록
ord-92e2953887524df6b32e2ef4598bd23f
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486512

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