Methanol → 2-Phenoxybenzaldoxime

HRID 376043

반응식

HRID 376043 반응식
[O:1]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.Cl.[NH2:19][OH:20]>O>[O:1]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=[N:19][OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 88060o-PhenoxybenzaldehydeHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 7374792-Phenoxybenzaldoxime수율 74.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

To 2-phenoxybenzaldehyde (4.96 g, 0,025 mole) were added anhydrous methanol (50 ml) and hydroxylamine hydrochloride (2.08 g, 0.03 mole), and the mixture was stirred at 60° C. for 3 hours. After completion of the reaction, water (200 ml) was added to the reaction mixture, which was extracted with methylene chloride and dried over magnesium sulfate. The crude product obtained by concentration under reduced pressure was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain 2-phenoxybenzaldoxime (3.95 g, yield: 74.1%) as a colorless oil.

후처리

  1. additionwas added to the reaction mixture, which
  2. extractionwas extracted with methylene chloride
  3. dry with materialdried over magnesium sulfate
  4. customThe crude product obtained by concentration under reduced pressure
  5. customwas purified by silica gel chromatography (ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-c47a8e14fc5e44968bc82ea373aac1e0
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05488159

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