Water → Methyl 6-formylpyridine-2-carboxylate

HRID 376298

반응식

HRID 376298 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][OH:12])[N:6]=1)=[O:4].O>ClCCCl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[O:12])[N:6]=1)=[O:4]

참가 물질

5

반응물 2

HCID 962WaterHCID 11513809Methyl 6-(hydroxymethyl)picolinate

생성물 1

HCID 12575850Methyl 6-formylpyridine-2-carboxylate수율 79%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 111,2-Dichloroethane용매

실험 절차

A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered.

후처리

  1. customformed continuously
  2. customThe solid is removed by filtration on celite
  3. customthe dichloromethane is evaporated off

출처 및 근거

ORD 기록
ord-7eeb93095125479cbb6978ebce1004e3
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020345

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