Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine
반응식
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1참가 물질
4
실험 절차
To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH (10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).
후처리
- customvolatile solvent was removed in vacuo
- extractionextracted with CHCl3(3×)
- washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
- customevaporated
출처 및 근거
- ORD 기록
- ord-f79ec0dd0b9e40458cd8ee59575cc942
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06020343
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