Water → (S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

HRID 376405노트

반응식

HRID 376405 반응식
[NH2:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4].O.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4])(=[O:25])[CH3:24]

참가 물질

4

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 53753679(S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid

생성물 1

HCID 53666229(S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

실험 절차

A suspension of (S)-2-amino-4-dibenzofuran-2-yl-4-oxo-butyric acid (0.025 g, 0.000082 mol) obtained above in Example 3 in acetic anhydride (2 mL) and water (4 mL) was sonicated (Cole Parmer 8850 Ultrasound Bath) for 15 minutes at room temperature. The resulting solution was then concentrated in vacuo, and the resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50, v/v) to yield the title product as a white solid; mp 166-170° C.

후처리

  1. concentrationThe resulting solution was then concentrated in vacuo
  2. customthe resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50

출처 및 근거

ORD 기록
ord-cc612f1cba554f73be4d2dd05f786133
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020366

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