Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylate

HRID 376460노트

반응식

HRID 376460 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]=O)[N:4]=[N:3]1.[CH3:9][O:10][C:11]([CH:13]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:12]>ClCCl>[CH3:9][O:10][C:11](=[O:12])/[CH:13]=[CH:7]/[C:5]1[N:4]=[N:3][N:2]([CH3:1])[CH:6]=1

참가 물질

4

반응물 2

HCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 143134381-Methyl-1H-1,2,3-triazole-4-carboxaldehyde

생성물 1

HCID 21202730Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylate수율 212.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-Methyl-1,2,3-triazol-4-carboxaldehyde (1 g, 9 mmol) was added to a solution of methoxycarbonylmethylene triphenylphosphorane (4.5 g, 13.5 mmol) in dichloromethane (50 ml) and stirred at room temperature for 3.5 hours. The solvent was removed and the residue purified by silica gel chromatography to afford the title compound, (3.2 g).

후처리

  1. customThe solvent was removed
  2. customthe residue purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-306f5d0ea46a40ce95e15948c0726ac3
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020368

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