Water → 4-(Amino-hydroxyimino)methylbenzoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[N:11])=[CH:6][CH:5]=1.Cl.[NH2:14][OH:15].C(=O)([O-])O.[Na+].O>CO>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[N:11][O:15][NH2:14])=[CH:6][CH:5]=1참가 물질
6
실험 절차
In 200 ml of methanol were dissolved 16.5 g of 4-cyanobenzoic acid methyl ester and 7.2 g of hydroxylamine hydrochloride. To the solution was added 8.82 g of sodium hydrogencarbonate at room temperature. The mixture was heated for 3 hours under reflux. The reaction mixture was cooled, to which was added 400 ml of water. Resulting crystalline precipitate was collected by filtration, which was washed with water and ether, followed by drying under reduced pressure to afford 16.1 g of the titled compound as colorless needles.
후처리
- temperatureThe mixture was heated for 3 hours
- temperatureunder reflux
- temperatureThe reaction mixture was cooled, to which
- filtrationResulting crystalline precipitate was collected by filtration, which
- washwas washed with water and ether
- customby drying under reduced pressure
출처 및 근거
- ORD 기록
- ord-6695f32bf3964c77b3ffb225e94d8322
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06020334
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