Toluene → 1,1,1,3,3,3-Hexafluoropropane

HRID 37692

반응식

HRID 37692 반응식
[CH:1](C(OC)(F)F)([C:6]([F:9])([F:8])[F:7])[C:2]([F:5])([F:4])[F:3].CCOCC.C1(C)C=CC=CC=1>[Ni].O>[CH2:1]([C:6]([F:9])([F:8])[F:7])[C:2]([F:5])([F:4])[F:3]

참가 물질

6

반응물 3

HCID 1140TolueneHCID 3283Diethyl EtherHCID 454591,1,1,3,3-Pentafluoro-3-methoxy-2-(trifluoromethyl)propane

생성물 1

HCID 127221,1,1,3,3,3-Hexafluoropropane

시약·촉매·용매 2

HCID 935Nickel촉매HCID 962Water용매

실험 절차

A 100 g mixture containing 59.0% (CF3)2CHCF2OCH3 (ether A), 20% (CF3)2C=CFOCH3 (ether B), 15.9% toluene and 150 mL water was heated in a Hastelloy™ nickel alloy tube for 3 hours at 135° C. and 6 hours at 200° C. The volatiles were bubbled through a solution of aqueous NaOH and a CaSO4 drying column, and condensed in a dry ice cooled trap to give 12.9 g HFC-236fa identified by its infrared spectrum. The liquid contents of the tube contained two layers. The upper layer, 14.9 g, was shown by 1H and 19F NMR spectroscopy to contain 16.5 wt. percent HFC-236fa and toluene. The combined HFC-236fa from the volatiles and the toluene corresponded to a yield of 15.4 g, 29.0% based on the starting ethers.

후처리

  1. customThe volatiles were bubbled through a solution of aqueous NaOH
  2. customa CaSO4 drying column, and condensed in a dry ice cooled trap

출처 및 근거

ORD 기록
ord-df84a772670642cab8123906239edb38
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420368

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