Water → 2-[2-[(3-Methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazole

HRID 377299노트

반응식

HRID 377299 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[C:16]([O:18][CH:19]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:20](=O)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=O)[CH:6]=[CH:7][CH:8]=1.C([O-])(=O)C.[NH4+:38].O.ClCCl>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[C:16]2[O:18][C:19]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:38]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6344DichloromethaneHCID 517165Ammonium AcetateHCID 542348532-Oxo-1,2-diphenylethyl 2-[(3-methoxy-phenyl)methyl]cyclohexanecarboxylate

생성물 1

HCID 193584162-[2-[(3-Methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazole수율 93.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 2-oxo-1,2-diphenylethyl 2-[(3-methoxy-phenyl)methyl]cyclohexanecarboxylate (440 mg) and ammonium acetate (593 mg) in acetic acid (2.4 ml) was refluxed for 3 hours and cooled to room temperature, and a mixture of water and dichloromethane was added thereto. The organic layer was washed with water and sodium bicarbonate aqueous solution, dried over magnesium sulfate, and evaporated in vacuo to afford 2-[2-[(3-methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazole (394 mg).

후처리

  1. additionwas added
  2. washThe organic layer was washed with water and sodium bicarbonate aqueous solution
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-30e180bced7d4a37807ea11899456731
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06025375

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