Glyceraldehyde → Ethyl acetate methanol ammonium hydroxide
반응식
[N:1]1(CC[O:8]C2C=CC(CC3C4C=CC=CC=4SC=3C3C=CC(CCN)=CC=3)=CC=2)CCCC1.[O:34]=[CH:35][CH:36]([CH2:38][OH:39])O.[C:40](O[BH-](OC(=O)C)OC(=O)C)(=[O:42])[CH3:41].[Na+]>ClCCl.CO>[NH4+:1].[OH-:8].[CH3:35][OH:34].[CH3:41][CH2:40][O:42][C:38]([CH3:36])=[O:39]참가 물질
5
실험 절차
3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (113 mg) was dissolved in dichloromethane:methanol (2:1, 6.0 mL), treated with glyceraldehyde (25 mg) and sodium triacetoxyborohydride (60 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated, and column chromatography with NH4OH:MeOH:EtOAc (3:7:90) afforded the product (56 mg).
후처리
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-1a415f14033b4c91b21f175517078ddb
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06025382
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