Toluene → HCID 53778754, 화합물

반응식

[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:12])=O.[C:14]1([CH3:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Cl:12][CH:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:3]1[CH:2]=[C:1]([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=1

참가 물질

반응물 3

HCID 1140Toluene

HCID 8794Phenylacetonitrile

HCID 24386Thionyl Chloride

생성물 1

HCID 53778754HCID 53778754, 화합물

실험 절차

9 g of 3-hydroxyphenylmethyl)phenylacetonitrile are dissolved in 150 ml of toluene and treated with stirring with 5.8 ml (80 mmol) of thionyl chloride. The reaction mixture is heated to reflux temperature and stirred for one hour. In the course of this, approximately 50 ml of toluene are removed in a water separator. The solvent is removed and 3-(chlorophenyl-methyl)phenylacetonitrile is obtained.

후처리

additiontreated
temperatureThe reaction mixture is heated
temperatureto reflux temperature
customIn the course of this, approximately 50 ml of toluene are removed in a water separator
customThe solvent is removed

출처 및 근거

ORD 기록: ord-715a8484b6f945f58156c48cdbcf18eb
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06028080

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