Water → 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

HRID 377609

반응식

HRID 377609 반응식
[CH3:1][N:2]1[C:9](=[O:10])[CH2:8][C:6](=O)[NH:5][C:3]1=[O:4].O.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:6]1[NH:5][C:3](=[O:4])[N:2]([CH3:1])[C:9](=[O:10])[CH:8]=1

참가 물질

4

반응물 3

HCID 962WaterHCID 24813Phosphorus oxychlorideHCID 757221-Methyl-2,4,6(1H,3H,5H)-pyrimidinetrione

생성물 1

HCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

실험 절차

1-Methylbarbituric acid (10 g) was suspended in phosphorus oxychloride (70 ml). Water (2 ml) was added and the mixture was heated at reflux for 40 minutes. The reaction was allowed to cool and was then concentrated under reduced pressure. The residue was poured onto a mixture of ice and water (200 ml). When the ice had melted, the precipitated solid was collected, washed with water and dried in vacuo at 50° C. to give the sub-title compound (6.86 g) as a yellow solid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 40 minutes
  3. temperatureto cool
  4. concentrationwas then concentrated under reduced pressure
  5. additionThe residue was poured onto a mixture of ice and water (200 ml)
  6. customthe precipitated solid was collected
  7. washwashed with water
  8. customdried in vacuo at 50° C.

출처 및 근거

ORD 기록
ord-4b900d2df6f8472bb0082e6245023774
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028074

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