Boron trifluoride etherate → N-p-Methoxybenzyloxycarbonyl-O-methyl-D-serine benzyl ester

HRID 3777

반응식

HRID 3777 반응식
[CH2:1]([O:8][C:9](=[O:26])[C@@H:10]([CH2:24][OH:25])[NH:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27](=O)=O.CC(C)=O.B(F)(F)F.CCOCC.[N+](=C)=[N-]>ClCCl>[CH2:1]([O:8][C:9](=[O:26])[C@@H:10]([CH2:24][O:25][CH3:27])[NH:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 8000Boron trifluoride etherateHCID 9550DiazomethaneHCID 13652495N-p-methoxybenzyloxycarbonyl-D-serine benzyl esterHCID 18522661Acetone cardice

생성물 1

HCID 13652497N-p-Methoxybenzyloxycarbonyl-O-methyl-D-serine benzyl ester수율 70%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The N-p-methoxybenzyloxycarbonyl-D-serine benzyl ester (720 mg, 2.00 mmol) is dissolved in dry dichloromethane (20 ml) and the solution cooled to dry ice/acetone. Boron trifluoride etherate (100 μl) is added followed by the portionwise addition of diazomethane (30 mmol in 20 ml CH2Cl2). After about 30 minutes the solution is filtered and washed once with water (10 ml), then dried (MgSO4) and evaporated to dryness. The resulting residue is chromatographed on silica gel using chloroform as eluant to give the pure title compound as an oil (520 mg, 70%) which crystallises on standing to give a colourless solid of m.p. 68°-69° C.; [α]D20 -1.3° (c 4.0, CHCl3).

후처리

  1. filtrationAfter about 30 minutes the solution is filtered
  2. washwashed once with water (10 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated to dryness
  5. customThe resulting residue is chromatographed on silica gel

출처 및 근거

ORD 기록
ord-3d9fe4eea0d14c78998610d953418f18
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722924

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