Propylene Oxide → Gadoteridol

HRID 377783

반응식

HRID 377783 반응식
[Na+].[N:2]1([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3]1.[Na+].[Na+].[CH2:28]1[O:31][CH:29]1[CH3:30].[Gd:32]>>[CH3:28][CH:29]([OH:31])[CH2:30][N:11]1[CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3][N:2]([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12]1.[Gd+3:32]

참가 물질

4

반응물 3

HCID 6378Propylene OxideHCID 23982GadoliniumHCID 108625271,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt

생성물 1

HCID 60714Gadoteridol

실험 절차

The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 292689, with propylene oxide to give the alkylated product, which can easily be complexed with gadolinium to give the final Gadoteridol.

후처리

  1. customto give the alkylated product, which

출처 및 근거

ORD 기록
ord-22b37d882ab74f81b1ae130093ff3ebd
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028194

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